University of Southern California Center for Neural Engineering The USC Andrew and Erna Viterbi School of Engineering USC

MIN-CHI HSIAO


3641 Watts Way, Los Angeles, California 90089-2520
Tel: (213)590-7338
email: minchi.hsiao at gmail.com
 
EDUCATION
 
University of Southern California (USC), Los Angeles, CA
Ph.D. in Biomedical Engineering, May 2009
Advisor: Dr. Theodore W. Berger
Dissertation: Developing a Neural Prosthesis for Hippocampus: Proof-of-Concept using the in vitro Slice
 
Chung Yuan Christian University (CYCU), Chung Li, Taiwan
Master of Science in Biomedical Engineering, Jul. 2000
Advisor: Dr. Jui-Hsiang Hsieh
Thesis: The Relationship between the Vagal Nuclei of the Lower Brain Stem and the Respiration
 
Bachelor of Science in Biomedical Engineering, Jul. 1998
Special Topic Research: The Relationship between the Respiratory Rhythm Area and the Phrenic Nerve
 
RESEARCH EXPERIENCE
 
Center for Neural Engineering, USC, Los Angeles, CA
Postdoctoral research associate, Jun. 2009 - present
      ¨ Neural responses elicited by ultrasound stimulation of the hippocampus
      ¨ Characterization of electrophysiological patterns of human hippocampal slices from epileptic patients

Department of Biomedical Engineering, USC, Los Angeles, CA
Research assistant, Aug. 2003 - May 2009
¨ Conduct extracellular recording experiments in rats’ hippocampal slices using planar multielectrode array
¨ Construct mathematical models for hippocampal neural networks
¨ Organize an interdisciplinary, multi-laboratory team for the hippocampal prosthesis project
 
Lab. of Neuralregeneration, Taipei Veterans General Hospital, Taipei, Taiwan
Research assistant, Apr. 2002 - Apr. 2003
¨ Chronic multielectrode array implant in rats’ lumbar spinal cords
¨ Neural ensemble recordings of lumbar cord motor neurons in behaving rats
¨ Analyze extracellular neural recordings using spike sorting techniques
¨ Behavioral assessment in a spinal cord injury rat model
¨ Histological studies in rats’ lumbar spinal cords
 
Lab. of Neurophysiology, CYCU, Chung Li, Taiwan
Research assistant, Sep. 1998 - Jul. 2000
¨ Stereotaxic surgery on the medulla of turtles
¨ Whole bundle nerve recordings of turtle respiratory nerves
¨ Chemical injections in medulla cardiorespiratory region in anesthetized turtles
Student researcher, Sep. 1997 - Jul. 1998
¨ Open-chest surgery for neuron tracer injections in cats’ phrenic nerves
¨ Histological studies in cats’ brainstems and cervical spinal cords
  
RESEARCH INTERESTS
 
¨ Neural responses elicited by ultrasound stimulation of the hippocampus
¨ Hippocampal-cortical cognitive neural prostheses
¨ Nonlinear dynamic modeling of neural systems
¨ Pharmacological effects in hippocampal trisynaptic circuitry
¨ Electrophysiology studies of mammals’ and reptiles’ brainstems and cardiorespiratory systems
 
PUBLICATIONS

Journal Papers

A method for unit recording in the lumbar spinal cord during locomotion of the conscious adult rat. Journal of Neuroscience Methods 2009 182(1): 49-54. Berg RW, Chen MT, Huang HC, Hsiao MC, Cheng H.
Hippocampal-Cortical Neural Prostheses to Restore Lost Cognitive Function. “EMBS Special Issue: Toward Biomimetic MicroElectronics as neural Prostheses” 2005 Sep-Oct;24(5):30-44. Berger TW, Ahuja A, Courellis SH, Deadwyler SA, Erinjippurath G, Gerhardt GA, Gholmieh G, Granacki JJ, Hampson R, Hsiao MC, LaCoss J, Marmarelis VZ, Nasiatka P, Srinivasan V, Song D, Tanguay AR, Wills J.
Custom-designed high-density conformal planar multielectrode arrays for brain slice electrophysiology. Journal of Neuroscience Methods 2006 152: 116-129 Gholmieh G, Soussou W, Han M, Ahuja A, Hsiao MC, Song D, Tanguay AR Jr and Berger TW.
The relationship between FTL and NA, DMV or CVLM in central cardiovascular control. Chinese Journal of Physiology. 44(4):169-79, 2001 Dec 31. Hsieh JH, Chang YC, Chung JL, Hsiao MC, Chen SC, Yen CT, Chai CY.
 

Reviewed Conference Papers

Using an open-loop inverse control strategy to regulate CA1 nonlinear dynamics for an in vitro hippocampal prosthesis model. 31th Annual International IEEE EMBS Conference pp.1529-32. September 2-6, 2009, Minneapolis, USA
Control theory-based regulation of hippocampal CA1 nonlinear dynamics30th Annual International IEEE EMBS Conference pp.5535-38. August 20-24, 2008, Vancouver, Canada
VLSI Implementation of a Nonlinear Neuronal Model: A “Neural Prosthesis” to Restore Hippocampal Trisynaptic Dynamics. 28th IEEE EMBC Annual International Conference. August 30~September 3, 2006, New York, USA
Modeling Hippocampal Nonlinear Dynamic Transformations with Principal Dynamic Modes 28th IEEE EMBC Annual International Conference. August 30~September 3, 2006, New York, USA
In Vivo Extracellular Recording of Spinal Neurons in the Awake, Freely Moving Rat. The 21th Joint Annual Conference of Biomedical Science, March 2006, Taiwan
Modeling Hippocampal Nonlinear Dynamic Transformations with Principal Dynamic Modes. 28th IEEE EMBC Annual International Conference.August 30~September 3, 2006, New York, USA
Cortical Prosthesis: Proof-of-Concept in Hippocampus Slice. NINDS Neural Interfaces Workshop. September 7~9, 2005, Bethesda, Maryland, USA
Implantable Biomimetic Electronics as Neural Prostheses for Lost Cognitive Function. Asian-Pacific Conference on Medical and Biological Engineering, April 24~27, 2005, Tsukuba, Ibaraki, Japan
Real Time Hardware Neural Spike Amplitude Extraction. IEEE International Workshop On Biomedical Circuit And Systems. December 1~3, 2004 Singapore
The Relationship between the Vagal Nuclei of the Lower Brain Stem and the Respiration. The 15th Joint Annual Conference of Biomedical Science, March 2000, Taiwan
The Relationship between the Respiratory Rhythm Area and the Phrenic Nerve. The 13th Joint Annual Conference of Biomedical Science, March 1998, Taiwan
 

Conference Abstracts and Presentations

Using a Modeling-Control Paradigm to Regulate CA1 Nonlinear Dynamics. Society for Neuroscience 39th Annual Meeting, October 17~21, 2009, Chicago, USA
Control Theory-based Regulation of Hippocampal CA1 Nonlinear Dynamics. Society for Neuroscience 38th Annual Meeting, November 15~19, 2008, Washington, DC, USA
Modeling CA1 Nonlinear Dynamics for a Hybrid biological-VLSI Hippocampal Slice using Control Theory. Biomedical Engineering Society 2007 Annual Meeting,September 26~29, 2007, Los Angeles, California, USA
A Neural Prosthesis for Hippocampus: Proof-of-Concept using the in vitro Slice. Society for Neuroscience 36th Annual Meeting, October 14~18, 2006, Atlanta, Georgia, USA
A Neural Prosthesis for Hippocampus: Reproduce Hippocampal CA1 Output in vitro using Control Theory. Society for Neuroscience 36th Annual Meeting, October 14~18, 2006, Atlanta, Georgia, USA
In Vivo Extracellular Recording of Spinal Neurons in the Awake, Freely Moving Rat. Society for Neuroscience 35th Annual Meeting, November 12~16, 2005, Washington DC, USA
A Biomimetic Electronic Prosthetic for the Hippocampus: Nonlinear Input/Output Model of CA3. Society for Neuroscience 34th Annual Meeting, October 23~27, 2004, San Diego, California, USA
A Biomimetic Electronic Prosthetic for Hippocampus: Proof-of-Concept Using the in vitro Slice. Society for Neuroscience 34th Annual Meeting, October 23~27, 2004, San Diego, California, USA
 

Book Chapters

Brain-Implantable Biomimetic Electronics as Neural Prostheses to Restore Lost Congnitive Function. “Handbook of Neural Engineering” Theodore W. Berger, Ashish Ahuja, Spiros H. Courellis, Gopal Erinjippurath, Ghassan Gholmieh, John J. Granacki, Min-Chi Hsiao, Jeff LaCoss, Vasilis Z. Marmarelis, Vijay Srinivasan, Dong Song, Armand R. Tanguay, Jr., Jack Wills. Edited by Metin Akay. (January 2007, Wiley-IEEE Press). ISBN: 9780470056691
Brain-Implantable Biomimetic Electronics as Neural Prostheses to Restore Lost Congnitive Function. “Synaptic Plasticity: Basic Mechanisms to Clinical Applications” Theodore W. Berger, Ashish Ahuja, Spiros H. Courellis, Gopal Erinjippurath, Ghassan Gholmieh, John J. Granacki, Min Chi Hsaio, Jeff LaCoss, Vasilis Z. Marmarelis, Vijay Srinivasan, Dong Song, Armand R. Tanguay, Jr., Jack Wills.Edited by Michel Baudry, Xiaoning Bi and Steven S. Schreiber. (April 2005, Informa Healthcare) ISBN: 0824759001
Mapping SpatioTemporal Electrophysiological Activity in Hippocampal Slices with Conformal Planar Multi-electrode Arrays.“Advances in Network Electrophysiology” Walid Soussou, Ghassan Gholmieh, Martin Han, Ashish Ahuja, Dong Song, Min-Chi Hsiao, Zhuo Wang, Armand R. Tanguay Jr., Theodore Berger. Edit by Makoto Taketani and Michel Baudry (May 2006, Springer). ISBN: 0387258574
Microelectrode-based epilepsy therapy: A hybrid neural prosthesis incorporating seizure prediction and intervention with biomimetic maintenance of normal hippocampal function. “Computational Neuroscience in Epilepsy” Stephens, M.L., Spencer, D.D., Cavus, I., Hsiao, M-C., Song, D., Deadwyler, S.A., Hampson, R.E., Putz, D., Quintero, J.E., Bensalem-Owen, M.K., Hascup, K.N., Rutherford. E.C., Day, B.K., Nickell, J.R., Pomerleau, F., Huettl, P., Burmeister, J.J., Talauliker, P.M., Marmarelis, V.Z., Granacki, J.J., Berger, T.W., and Gerhardt, G.A.   Edit by Ivan Soltesz and Kevin Staley. (February, 2008, Elsevier) ISBN: 0123736498
 
 
COMPETENT TECHNIQUES
 
¨ Stereotaxic surgery in small animals
¨ In vivo and in vitro electrophysiology experimentation
¨ Chronic electrode implants and ensemble neural recordings
¨ Extracellular and whole bundle nerve recording techniques
¨ Nonlinear system analysis
¨ Hardware maintenance and basic design
¨ MATLAB, MS Office applications, Adobe Photoshop, Illustrator, Premium, and 3D Studio Max
 
OTHER EXPERIENCE
 
Taichung Armed Forces Hospital, Taichung, Taiwan
Leading cadre, Mar. 2001 - Mar. 2002
¨ Lead a team of 100+ members executing hospital service support
¨ Accounted for the education and training affairs of the corps
¨ Leader of the first-aid team of the corps
Medical officer, Aug. 2000 - Mar. 2002
¨ Maintenance of medical equipment and purchase of medicine
¨ Administrative work in the Office of Training Officer
 
Dept. of Biomedical Engineering, CYCU, Chung Li, Taiwan
Teaching assistant, Sep. 1998 - Jul. 2000
¨ Physiology: Graded written assignments and exams
 
Tri-Service General Hospital, Taipei, Taiwan
Student intern, Jul. 1997 - Aug. 1997
¨ Repair of clinical medical equipment in the Office of Biomedical Engineering 
  
HONORS and AWARDS
 
¨ Studying Abroad Scholarship (2004 & 2005), granted by Ministry of Education, Taiwan, cash prize, 60 students per year, nationwide
¨ Elite Scholarship (1998 & 1999), granted by CYCU, Dept. of Biomedical Engineering, monthly stipend, top 2 students per year
¨ Kolinic Scholarship (1996), granted by Kolinic Biomedical Instrumentation Inc. cash prize, top 1% departmental
¨ Certificate of Distinguished Service Award (1997), granted by CYCU